MODEL MK-2000ST

NP-NIBP MONITOR FOR MICE & RATS

Introducing the first and only Non-Preheating, Non-Invasive
Blood Pressure Monitor for Mice and Rats in the world

Capable of recording from neonatal mice (1.4 g) to aged rats (1 kg)

Introduction

 To measure blood pressure of small animals such as rats or mice using conventional BP Monitors, animals had to be preheated by some means. However, the advent of MK-2000 has made it possible to measure blood pressure without preheating animals provided that the room temperature is at least 23 degrees C. MK-2000ST is the successor to MK-2000 and has become more compact than ever before.
MK-2000ST is ideal for investigating the effects of drugs on animals.  Once the animals are restrained properly, just press the START key and HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP) and DBP (Diastolic BP, calculated value) will be automatically measured.

 It photoplethysmographically measures pulsatile blood pressure of tail arteries. Pulses are stored into the computer memory and the peak levels of the pulses are plotted on the display. X-axis indicates cuff pressure, and Y-axis indicates amplitude of pulses. Using this method, the operator can decrease the risk of selecting artifacts and BP measurement is made more objective compared to the conventional digital display method.

 SBP is initially estimated by inflating the cuff at approximately 25 mmHg/sec. During cuff deflation at about 4-5 mmHg/sec, SBP is determined precisely. SBP is defined as the point when the pulse reappears..

Main Features

1. Two operation modes are available.
With Mode 1 HR (Heart Rate) and SBP (Systolic Blood Pressure) are measured. With Mode 2 HR, SBP, MBP (Mean Blood Pressure) and DBP (Diastolic Blood Pressure, calculated value) can be measured.

NOTE：HR (Heart Rate), SBP (Systolic BP), MBP (Mean BP), DBP (Diastolic BP, calculated value)

2. Continuous Measurement Function
Continuous measurement can be performed up to ten (10) times. Further, continuous & rapid measurement can also be performed in order to shorten the measuring time.

3. Rapid Printout Function
Onscreen data including average (AV) and standard deviation (SD), are printed out in about one (1) second by the high-performance thermal printer. Data may also be deleted at the operator's discretion.

4. Colored mice such as C57BL/6,  neonatal mice weighing 1.4 grams, hamsters (anaesthetized) and  guinea pigs (non-anaesthetized), of which blood pressure was so far considered difficult to measure, can be measured.

5. Sick animals can be measured. (e.g.  animal with cardiac infarction)

6. Multi-channel system is no longer needed. Just prepare multiple restrainers, and measurement can be done one after the other.

7.Auto-Sequence Function
Blood pressure of a tail artery of an animal can be monitored automatically at specified time intervals, which can be 1 - 99 minutes in length. At each interval, anywhere from 1-10 measurements can be made. This function invokes a series of procedures automatically--- measurement,  printout of data and transfer to a PC.

8. Time-Stamp Function
The MK-2000ST precisely records the time of each BP measurement.

9. Hard Copy Function
The screen on the display can be captured to the thermal printer using the PrtScreen key.

10. An RS-232C interface is provided on the rear panel of the main unit. Using the optional DCS-2000 Data Collection Software  (Windows Version) the data obtained can be exported to a personal computer and stored as a CSV file.

11. The animal holders are made of dark brown acryl, allowing BP measurement under relatively stress-free conditions.

12. Operation is very simple.

SPECIFICATIONS

Correlation between simultaneously recorded blood pressures (BP) from carotid catheter and BP measured with the Model MK-2000 in mice. Good correlation was seen in a wide range of BP, which was induced by i.v. infusions of pressor or depressor agents.

The data was offered courtesy of Prof. Tomoyuki Kuwaki, Ph.D.,
  Department of Molecular and Integrative Physiology, Graduate School of Medicine,
Chiba University

　　　　　　　　　　Specifications are subject to change without notice.

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    Institute, Osaka; 2Second Department of Internal Medicine, Nara Medical University, Nara; 3Department of
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       Tainan 70101, Taiwan, R.O.C.
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    1 Department of Biopharmaceutics, Nihon Pharmaceutical University
    2 National Institute of Health and Nutrition
    3 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    4 Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    5 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
    6 Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
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19. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice.
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    Cristina M. Alvira, Marlene Rabinovitch, Eric S. Shinwell, and Anjali Dixit
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California

Last Updated : June 06, 2008